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Although the majority of chemicals in cosmetic products present limited or zero danger, several dozen have been associated to substantial medical problems, such as cancer, reproductive and neurological harm, and developmental delays. Cosmetic chemicals invade a person's body through the skin, inhalation, ingestion and internal use, and cause similar problems as food chemicals, per this site.

Chemicals linked to cancer are found in food and various other ordinary products. However, no category of consumer products is susceptible to less government inspection than cosmetics, including Intellishade TruPhysical. Though many of the chemicals and contaminants in cosmetics very likely pose very little risk, being exposed to some has been linked to serious health issues, such as cancer.