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While many chemicals in beauty products and cosmetics present minimal or no threat, several dozen have been linked to significant health conditions, such as developmental delays and cancer. Cosmetic chemicals gain entry to the body through inhalation, ingestion, and the skin, and cause the same risks as food chemicals, per this site.

Chemicals linked to cancer are found in food and many other commonly used goods. However, no type of consumer goods is subject to less government management than cosmetics, including Girls' Night Out. Though most of the chemicals and contaminants in cosmetics and personal care products probably pose minimal risk, exposure to some has been linked to critical health concerns, such as cancer.