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Though many chemicals in beauty products and cosmetics present minimal or absolutely no risk, several dozen have been linked with substantial health problems, including developmental delays and cancer. Chemicals in cosmetics enter the body through internal use, the skin, and inhalation, and cause similar problems as food chemicals, per this site.

Chemicals and contaminants associated with cancer are found in food, water, and various other everyday goods. But, no classification of consumer goods is subject to less government inspection than cosmetics and other personal care products, including Girls' Night Out. Although most of the contaminants and chemicals in cosmetics and personal care products almost certainly pose minimal risk, being exposed to some has been associated with major health conditions, including cancer.