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Though the majority of chemicals in cosmetic products pose limited or no risk, some have been associated to severe health conditions, such as cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics invade a person's body through inhalation, ingestion, and the skin, and cause similar problems as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in food, water, and many other ordinary goods. But, no type of consumer goods is susceptible to less government direction than cosmetics and other personal products, including Once Upon A Mani. While many of the chemicals in cosmetics likely present very little risk, exposure to some has been associated with significant health problems, including cancer.