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Though most chemicals in cosmetics pose minimal or absolutely no danger, several dozen have been associated with significant medical issues, such as cancer, and neurological harm. Cosmetic chemicals get into a person's body through ingestion, inhalation, and internal use, and pose similar dangers as food chemicals, per this site.

Chemicals and contaminants associated with cancer can be found in water, food, and many other commonly used products. However, no area of consumer products is accountable to less government inspection than cosmetics and other personal care products, including Lace 'Em Up. Although most of the chemicals in cosmetics and personal care products almost certainly present little risk, subjection to a few has been associated with worrying health concerns, such as cancer.