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Although the majority of chemicals in cosmetics pose little or zero threat, several have been associated to severe medical conditions, including cancer, reproductive and neurological harm, and developmental delays. Cosmetic chemicals invade the body through internal use, the skin, and inhalation, and pose the same problems as food chemicals, per this site.

Contaminants and chemicals associated with cancer are found in water, food, and various other commonly used goods. Yet, no category of consumer goods is accountable to less government inspection than cosmetics and other personal products, including Sparkling Red Slippers. Although most of the chemicals and contaminants in cosmetics and personal care products in all likelihood pose little risk, subjection to some is associated with worrying health problems, such as cancer.