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While many chemicals in cosmetic products pose little or no threat, dozens have been associated with serious health issues, including cancer, and neurological harm. Cosmetic chemicals can enter the body through the skin and inhalation, and cause the same problems as food chemicals, per this site.

Contaminants and chemicals linked to cancer can be found in food and various other common items. Still, no group of consumer items is accountable to less government direction than cosmetics, including Smackers Nail Polish. Though many of the chemicals and contaminants in cosmetics likely pose very little risk, exposure to some has been linked to substantial health issues, including cancer.