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Although the majority of chemicals in cosmetic products pose limited or absolutely no danger, several are associated with considerable medical issues, including neurological harm and cancer. Chemicals in cosmetics gain entry to a person's body through inhalation, ingestion, and the skin, and lead to the same dangers as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in food, water, and various other everyday products. However, no area of consumer products is subject to less government direction than cosmetics, including Chain Reaction. While many of the chemicals in cosmetics and personal care products almost certainly present very little risk, being exposed to a few has been associated with critical health conditions, including cancer.