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While the majority of chemicals in cosmetics present little or no threat, several are linked with serious health conditions, including developmental delays and cancer. Cosmetic chemicals get into a person's body through ingestion, inhalation, and internal use, and lead to similar problems as food chemicals, per this site.

Chemicals and contaminants associated with cancer are found in food, water, and several other commonly used products. However, no area of consumer products is subject to less government inspection than cosmetics and other personal products, including Pun Up Girl. Although many of the chemicals in cosmetics probably present very little risk, being exposed to a few is associated with serious health disorders, including cancer.