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While the majority of chemicals in cosmetics pose little or zero threat, some are linked with substantial health problems, such as cancer, reproductive and neurological harm, and developmental delays. Cosmetic chemicals enter a person's body through internal use, the skin, and inhalation, and cause similar risks as food chemicals, per this site.

Chemicals associated with cancer can be found in water, food, and several other common items. But, no sector of consumer items is accountable to less government direction than cosmetics, including Metallix Gleam. Although many of the chemicals in cosmetics very likely pose very little risk, exposure to a few has been associated with serious health problems, such as cancer.