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Although many chemicals in cosmetics pose slight or zero risk, several dozen are associated to substantial health problems, including neurological harm and cancer. Cosmetic chemicals can enter a person's body through inhalation, ingestion, and the skin, and pose similar risks as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in food, water, and several other commonly used items. Still, no type of consumer items is subject to less government management than cosmetics, including I Know I Look Good. Although many of the chemicals in cosmetics probably present minimal risk, exposure to a few has been associated with critical health issues, such as cancer.