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Although most chemicals in beauty products present limited or zero risk, several dozen have been associated to significant health issues, such as cancer, and neurological harm. Chemicals in cosmetics can enter the body through the skin, inhalation, ingestion and internal use, and pose similar problems as food chemicals, per this site.

Chemicals linked to cancer can be found in food, water, and lots of other commonly used products. However, no sector of consumer products is subject to less government oversight than cosmetics, including Sapphire. While many of the contaminants and chemicals in cosmetics and personal care products likely present very little risk, subjection to a few has been linked to substantial health concerns, such as cancer.