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Though many chemicals in beauty products present minimal or zero threat, several have been associated to significant medical problems, such as cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics gain entry to the body through ingestion, inhalation, and internal use, and lead to the same problems as food chemicals, per this site.

Chemicals associated with cancer can be found in food and several other ordinary products. However, no category of consumer products is subject to less government oversight than cosmetics, including Roxie's Hart. Although most of the contaminants and chemicals in cosmetics and personal care products almost certainly present minimal risk, subjection to some has been associated with worrying health problems, including cancer.