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While many chemicals in cosmetic products pose very little or zero threat, dozens have been associated with substantial medical conditions, including cancer, and neurological harm. Chemicals in cosmetics can enter a person's body through inhalation, ingestion, and the skin, and pose similar problems as food chemicals, per this site.

Contaminants and chemicals linked to cancer can be found in water, food, and many other common goods. But, no area of consumer goods is subject to less government inspection than cosmetics and other personal products, including Roxie's Hart. Although many of the chemicals in cosmetics and personal care products likely present very little risk, exposure to a few has been linked to worrying health disorders, including cancer.