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Although the majority of chemicals in cosmetics present slight or absolutely no risk, several dozen have been associated to substantial health problems, such as neurological harm and cancer. Chemicals in cosmetics can enter a person's body through the skin, inhalation, ingestion and internal use, and lead to the same risks as food chemicals, per this site.

Chemicals associated with cancer are found in water, food, and many other commonly used items. Yet, no category of consumer items is subject to less government oversight than cosmetics, including One and Only. Though many of the contaminants and chemicals in cosmetics and personal care products very likely pose minimal risk, exposure to a few has been associated with significant health problems, such as cancer.