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Although most chemicals in beauty products present slight or absolutely no threat, several dozen are associated to substantial medical issues, such as cancer, reproductive and neurological harm, and developmental delays. Cosmetic chemicals can enter a person's body through internal use, the skin, and inhalation, and pose the same problems as food chemicals, per this site.

Chemicals and contaminants associated with cancer are found in food, water, and various other commonly used items. Yet, no area of consumer items is subject to less government inspection than cosmetics, including Charisma. While many of the chemicals in cosmetics most likely pose very little risk, exposure to a few has been associated with major health concerns, such as cancer.