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Although most chemicals in cosmetic products present minimal or zero threat, several dozen are associated with significant health problems, such as cancer, reproductive and neurological harm, and developmental delays. Cosmetic chemicals enter a person's body through inhalation, ingestion, and the skin, and cause similar problems as food chemicals, per this site.

Chemicals associated with cancer are found in water, food, and a lot of other commonly used goods. However, no area of consumer goods is accountable to less government inspection than cosmetics and other personal care products, including Sinful. While many of the chemicals and contaminants in cosmetics most likely present little risk, exposure to some has been associated with major health issues, such as cancer.