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While the majority of chemicals in cosmetics present minimal or no danger, several are associated to serious health conditions, including cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics can enter a person's body through inhalation, the skin, and ingestion, and pose similar dangers as food chemicals, per this site.

Contaminants and chemicals linked to cancer can be found in food, water, and various other everyday products. However, no sector of consumer products is susceptible to less government inspection than cosmetics, including PDX Pedix Feet Base Gel. Though most of the contaminants and chemicals in cosmetics very likely present minimal risk, being exposed to a few has been linked to critical health concerns, such as cancer.