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Although most chemicals in cosmetics present hardly any or zero threat, several dozen are associated to significant health problems, such as developmental delays and cancer. Cosmetic chemicals gain entry to a person's body through internal use, the skin, and inhalation, and cause the same risks as food chemicals, per this site.

Contaminants and chemicals linked to cancer are found in water, food, and a lot of other everyday items. Still, no classification of consumer items is susceptible to less government direction than cosmetics, including TruGel Dark Shadows. While many of the chemicals in cosmetics and personal care products probably present minimal risk, subjection to some has been linked to significant health conditions, such as cancer.