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Although the majority of chemicals in cosmetic products present little or no threat, some have been associated with substantial health problems, such as cancer, and neurological harm. Cosmetic chemicals gain entry to a person's body through the skin and inhalation, and pose similar dangers as food chemicals, per this site.

Chemicals and contaminants associated with cancer can be found in food and many other commonly used items. However, no group of consumer items is accountable to less government direction than cosmetics, including Gel-n-Base in One Gel Polish - Frostbite. Although many of the chemicals and contaminants in cosmetics almost certainly pose very little risk, being exposed to a few is associated with major health concerns, such as cancer.