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While the majority of chemicals in cosmetics present little or zero risk, some have been associated with considerable medical conditions, including cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics gain entry to the body through ingestion, inhalation, and internal use, and lead to similar dangers as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in water, food, and several other commonly used items. Yet, no kind of consumer items is accountable to less government oversight than cosmetics, including Gel-n-Base in One Gel Polish - Hang-Ten-Toes. While many of the chemicals and contaminants in cosmetics and personal care products likely present little risk, subjection to some has been associated with serious health issues, such as cancer.