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Although most chemicals in beauty products present very little or absolutely no risk, several have been associated to severe medical problems, including developmental delays and cancer. Cosmetic chemicals enter a person's body through internal use, the skin, and inhalation, and pose similar problems as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in water, food, and various other everyday items. However, no sector of consumer items is subject to less government oversight than cosmetics, including Sally Hansen Advanced Hard as Nails. Though many of the chemicals and contaminants in cosmetics almost certainly pose little risk, being exposed to a few has been associated with major health concerns, such as cancer.