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Although most chemicals in cosmetics present limited or no risk, several dozen have been associated with considerable health problems, such as cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics gain entry to a person's body through the skin and inhalation, and lead to the same problems as food chemicals, per this site.

Chemicals and contaminants associated with cancer are found in food and various other ordinary products. Still, no category of consumer products is accountable to less government direction than cosmetics, including Def Defying Lacquer. Though many of the chemicals and contaminants in cosmetics likely pose minimal risk, exposure to some is associated with substantial health disorders, such as cancer.