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Although most chemicals in cosmetics pose minimal or no risk, dozens have been associated with substantial medical issues, including cancer, reproductive and neurological harm, and developmental delays. Cosmetic chemicals invade the body through internal use, the skin, and inhalation, and lead to the same risks as food chemicals, per this site.

Chemicals and contaminants linked to cancer can be found in water, food, and various other everyday goods. Yet, no group of consumer goods is subject to less government oversight than cosmetics, including Manicure's Best Friend. Although most of the contaminants and chemicals in cosmetics and personal care products probably present little risk, exposure to a few has been linked to critical health issues, including cancer.