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Although the majority of chemicals in cosmetics present limited or zero threat, several dozen are associated to considerable medical problems, such as developmental delays and cancer. Chemicals in cosmetics invade a person's body through the skin, inhalation, ingestion and internal use, and cause the same problems as food chemicals, per this site.

Chemicals linked to cancer are found in food, water, and several other everyday items. However, no classification of consumer items is susceptible to less government management than cosmetics, including Trugel Burnt Sienna. Though many of the chemicals in cosmetics most likely present very little risk, exposure to a few has been linked to significant health concerns, including cancer.