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While most chemicals in beauty products present limited or zero risk, several are associated to considerable medical conditions, including developmental delays and cancer. Chemicals in cosmetics enter the body through inhalation, the skin, and ingestion, and cause similar risks as food chemicals, per this site.

Chemicals linked to cancer can be found in food and lots of other commonly used items. Still, no category of consumer items is susceptible to less government management than cosmetics, including Sally Hansen Smooth & Perfect. Though many of the chemicals in cosmetics and personal care products probably pose little risk, being exposed to a few has been linked to significant health disorders, including cancer.