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While the majority of chemicals in beauty products and cosmetics present hardly any or absolutely no danger, several dozen have been associated to serious health issues, including cancer, and neurological harm. Chemicals in cosmetics invade a person's body through inhalation, the skin, and ingestion, and cause the same dangers as food chemicals, per this site.

Chemicals associated with cancer are found in food, water, and many other common items. However, no type of consumer items is accountable to less government oversight than cosmetics and other personal care products, including Sally Hansen Smooth & Perfect. Though most of the contaminants and chemicals in cosmetics probably pose minimal risk, subjection to some has been associated with major health concerns, including cancer.