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Although many chemicals in beauty products pose slight or zero danger, some have been linked with significant medical conditions, such as developmental delays and cancer. Chemicals in cosmetics can enter the body through the skin, inhalation, ingestion and internal use, and lead to similar problems as food chemicals, per this site.

Chemicals associated with cancer are found in food, water, and various other everyday products. Still, no category of consumer products is susceptible to less government direction than cosmetics and other personal care products, including Perfect Smoothing Compact Foundation (Refill). Though most of the contaminants and chemicals in cosmetics and personal care products in all likelihood pose very little risk, being exposed to a few has been associated with substantial health concerns, including cancer.