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Though the majority of chemicals in cosmetic products present minimal or absolutely no danger, some have been associated to severe health issues, such as cancer, and neurological harm. Cosmetic chemicals enter a person's body through the skin and inhalation, and lead to similar risks as food chemicals, per this site.

Chemicals and contaminants associated with cancer can be found in water, food, and several other everyday goods. Yet, no sector of consumer goods is susceptible to less government inspection than cosmetics and other personal products, including Perfect Smoothing Compact Foundation (Refill). Though many of the chemicals in cosmetics and personal care products very likely present little risk, exposure to a few has been associated with serious health conditions, including cancer.