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While most chemicals in beauty products and cosmetics pose minimal or zero threat, several dozen have been linked with significant health issues, including developmental delays and cancer. Chemicals in cosmetics get into the body through internal use, the skin, and inhalation, and lead to the same risks as food chemicals, per this site.

Chemicals and contaminants associated with cancer are found in food, water, and various other common products. But, no category of consumer products is susceptible to less government management than cosmetics, including 45 Second Top Coat. While many of the contaminants and chemicals in cosmetics and personal care products almost certainly pose very little risk, your exposure to a few has been associated with serious health issues, such as cancer.