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Though the majority of chemicals in cosmetic products pose slight or no threat, several have been linked with severe health issues, including cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics invade the body through inhalation, ingestion, and the skin, and lead to similar dangers as food chemicals, per this site.

Contaminants and chemicals linked to cancer are found in food, water, and various other commonly used goods. However, no sector of consumer goods is susceptible to less government oversight than cosmetics and other personal care products, including 45 Second Top Coat. Though many of the chemicals and contaminants in cosmetics most likely pose very little risk, exposure to a few has been linked to critical health concerns, such as cancer.