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While many chemicals in beauty products and cosmetics pose hardly any or zero risk, several dozen are associated to considerable medical issues, such as cancer, and neurological harm. Cosmetic chemicals enter a person's body through inhalation, ingestion, and the skin, and pose the same problems as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in water, food, and many other everyday goods. But, no category of consumer goods is accountable to less government direction than cosmetics, including 45 Second Top Coat. Although most of the chemicals and contaminants in cosmetics and personal care products most likely pose little risk, exposure to a few is associated with significant health issues, including cancer.