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Although the majority of chemicals in beauty products pose minimal or zero threat, some have been associated to severe health conditions, such as cancer, and neurological harm. Cosmetic chemicals enter a person's body through the skin and inhalation, and lead to similar dangers as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in food and many other everyday goods. Still, no type of consumer goods is subject to less government inspection than cosmetics and other personal care products, including Rouge Soak Off Gel Polish. Though most of the contaminants and chemicals in cosmetics and personal care products very likely present minimal risk, subjection to some has been associated with serious health problems, including cancer.