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While many chemicals in beauty products present slight or zero threat, several are associated to substantial medical problems, including cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics enter the body through the skin and inhalation, and lead to similar problems as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in water, food, and many other commonly used products. But, no type of consumer products is subject to less government management than cosmetics, including Truly Tangerine. Though many of the chemicals in cosmetics very likely present very little risk, being exposed to a few has been associated with substantial health problems, such as cancer.