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Though most chemicals in cosmetic products present limited or absolutely no danger, some have been associated to substantial medical issues, such as cancer, reproductive and neurological harm, and developmental delays. Cosmetic chemicals enter a person's body through the skin and inhalation, and pose similar risks as food chemicals, per this site.

Chemicals associated with cancer can be found in food, water, and a lot of other common items. However, no classification of consumer items is accountable to less government oversight than cosmetics, including Pearl Buttons Soak Off Gel Polish. Although many of the chemicals and contaminants in cosmetics most likely pose little risk, subjection to a few has been associated with serious health concerns, including cancer.