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While many chemicals in cosmetics pose little or zero threat, dozens have been associated to significant medical issues, such as cancer, and neurological harm. Chemicals in cosmetics gain entry to a person's body through ingestion, inhalation, and internal use, and lead to similar problems as food chemicals, per this site.

Contaminants and chemicals associated with cancer are found in water, food, and a lot of other commonly used items. Yet, no area of consumer items is susceptible to less government oversight than cosmetics, including Lacquer Watermelon Rind. While many of the chemicals and contaminants in cosmetics and personal care products almost certainly present minimal risk, being exposed to a few has been associated with worrying health conditions, including cancer.