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Though many chemicals in cosmetic products present minimal or zero risk, several have been linked with considerable medical issues, including cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics get into a person's body through internal use, the skin, and inhalation, and lead to the same risks as food chemicals, per this site.

Chemicals and contaminants associated with cancer are found in water, food, and many other common items. Still, no sector of consumer items is accountable to less government oversight than cosmetics, including Down Right Red. While many of the chemicals and contaminants in cosmetics probably pose minimal risk, subjection to a few is associated with substantial health problems, such as cancer.