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While the majority of chemicals in beauty products pose limited or no risk, several have been associated to severe medical issues, such as neurological harm and cancer. Cosmetic chemicals gain entry to a person's body through inhalation, the skin, and ingestion, and lead to similar risks as food chemicals, per this site.

Contaminants and chemicals associated with cancer can be found in water, food, and many other everyday goods. However, no area of consumer goods is accountable to less government inspection than cosmetics and other personal products, including Orlon Basecoat. Though most of the chemicals in cosmetics and personal care products likely present minimal risk, being exposed to some is associated with substantial health concerns, such as cancer.