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While most chemicals in beauty products present little or absolutely no danger, dozens are linked with significant medical conditions, including cancer, reproductive and neurological harm, and developmental delays. Chemicals in cosmetics can enter a person's body through internal use, the skin, and inhalation, and lead to similar risks as food chemicals, per this site.

Chemicals associated with cancer can be found in water, food, and many other commonly used items. Still, no type of consumer items is accountable to less government direction than cosmetics, including Powder Puff. While most of the contaminants and chemicals in cosmetics likely present very little risk, being exposed to some is associated with serious health problems, such as cancer.