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Though the majority of chemicals in cosmetics present limited or no risk, some have been associated to substantial health problems, including cancer, and neurological harm. Cosmetic chemicals enter a person's body through the skin and inhalation, and lead to the same problems as food chemicals, per this site.

Chemicals and contaminants linked to cancer can be found in food and various other ordinary items. Yet, no category of consumer items is subject to less government oversight than cosmetics and other personal care products, including Sinful Color Nail Enamel Lie-Lac. While most of the contaminants and chemicals in cosmetics and personal care products almost certainly present very little risk, subjection to some has been linked to substantial health concerns, such as cancer.